TABLE 2.

Biochemical analysis of liver function after treatment

Liver function tests in malaria-infected mice on day 8 postinfection (p.i.) with or without administration of DFO (300 mg/kg) × 2 and NAC (250 mg/kg) mice for 5 consecutive days (3–7 days). The activity of the liver enzymes in serum is expressed in units/liter. Malaria-infected mice on day 0 is considered as control. The details of the methodology are described under “Experimental Procedures.”

Experimental groups	Biochemical analysis of liver function
	ALT	AST	ALP
	units/liter	units/liter	units/liter
Infected mice on day 0, p.i.	17.16 ± 1.72	44.8 ± 4.5	105.43 ± 11.34
Infected mice on day 8, p.i.	142.4 ± 14.21a	210.82 ± 20.5a	274.97 ± 30.56a
Infected on day 8, p.i.+ DFO	69.54 ± 6.96b	108.65 ± 9.56b	157.78 ± 16.12b
Infected on day 8, p.i.+ NAC	61.51 ± 6.78b	95.45 ± 9.66b	146.1 ± 13.89b
Infected mice on day 8, p.i. + rabbit serum	139.6 ± 13.88c	214.35 ± 20.5c	272.66 ± 28.89c
Infected mice on day 8, p.i. + anti-PMN antibody	77.76 ± 8.08b	121.94 ± 14.45b	177.93 ± 20.17b
Infected mice on day 8, p.i. + hamster IgG	144.76 ± 4.08c	207.96 ± 20.35c	271.21 ± 27.25c
Infected mice on day 8, p.i. + anti-TNF α antibody	59.41 ± 6.78b	91.32 ± 9.48b	137.81 ± 15.78b

^a Data were presented as mean ± S.E., p < 0.01 versus control.

^b p < 0.01 versus infection on day 8.

^c p < 0.001 versus infection on day 8, n = 6.