FIGURE 7.

Inhibition of kinase activity protects pneumococci from HAMLET-induced death. S. pneumoniae D39 were incubated with HAMLET in the absence or presence of the protein kinase inhibitor staurosporine (20 μm). After 1 h, cells were serially diluted and plated for viable counts, which are presented as log₁₀ of HAMLET-induced death. The data represent the mean ± S.D. of three individual experiments with error bars, and significance was calculated using the paired t test with a 95% confidence interval (** = p < 0.01).