Figure 3.

Spatial sensitivity of striatal inhibition. Intracellular recording (left panel) from one VS spiny projection neuron (SPN) in an anesthetized rat showing overlaid responses to tetanic electrical stimulation (arrows) in two different regions (S1, S2) of medial prefrontal cortex. Current injection into the neuron produces tonic firing (gray traces), which is inhibited by stimulation in one site (S1) and enhanced by stimulation in another (S2). The latency of the inhibitory component, its reversal potential (not shown), and data from other studies (see text) indicate that feed-forward inhibition from fast spiking (FS) striatal interneurons in VS and DMS is a likely source of this inhibition (right panel). Abbreviations are the same as for Figure 1. Adapted from Gruber et al. (2009b).