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Unique activation of VEGFRs by VEGF-E and Trimeresurus flavoviridis svVEGF. VEGF-E encoded in the Orf viral genome binds to and activates only VEGFR-2, inducing well-organized blood vessels. T. flavoviridis svVEGF stimulates vascular permeability by activation of VEGFRs in a specific manner.
