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A model for the WRC assembly in vivo. (A, B) Nudel binds to and prevents the degradation of the S-N-A complex and HSPC300 homotrimer, respectively. The interaction of Nudel with HSPC300 is less dynamic than with the S-N-A complex. (C) The possible assembly paths of the WRC. All the intermediate complexes were verified in the study, though how they eventually form the mature WRC is speculative (the question marks). See the text for detailed discussions.
