Table 6. Regulation of protein-folding molecular chaperones encoded by genes in Figure 2.
| Gene | Fold Change | Encoded Chaperone Activity | Human Homolog or Domain |
|---|---|---|---|
| SSA2 | ↑7.1 | Hsp70 family member, member of Rad9 DNA-checkpoint complex | Hsp70 |
| SSA1a | ↑4.2 | Hsp70 family, chaperone complex with ADJ1, protein refolding, member of Rad9 DNA-checkpoint complex | Hsp70 |
| HSP104a | ↑4.0 | Hsp100 family, acts in conjunction with Ssa1 and Ydj1 (Hsp40), protein refolding | |
| SSA3 | ↑3.8 | Hsp70 family member | HSPA1AB |
| HSP82 | ↑3.3 | Hsp90 isoform, associates with Cpr6, Sti1, Cns1, Hch1, Aha1, Sse1, nascent chain folding, protein refolding, proteasome assembly | HSP90AB1 |
| SIS1 | ↑2.7 | HSP40 (DNAJ) co-chaperone, interacts with Ssa1 | DNAJB1 [HSP40] |
| SSE1 | ↑2.6 | Hsp70 family member, component of Hsp90 chaperone complex, protein refolding | HSPA4 |
| HSC82a | ↑2.3 | Hsp90 isoform, associates with Sti1, Cns1, Cpr6, Hch1, Aha1, Sse1, nascent chain folding, protein refolding, proteasome assembly | HS90AB1 |
| STI1 | ↑1.9 | Hsp90 co-chaperone, interacts with Ssa and Hsp70 chaperones | STIP1 |
| SSA4 | ↑1.2 | Hsp70 family member | HSPA8 |
| CNS1b | ↓1.7 | Hsp90 co-chaperone, binds Hsp82 and Ssa1 | TTC4 |
a
Chaperone physically interacts with Blm10.
b
Essential gene.