Table 7. Additional protein-folding genes regulated ≥1.5-fold.
| Gene | Fold Change | Encoded Chaperone Activity | Human Homolog or Domain |
|---|---|---|---|
| HSP78 | ↑3.7 | Hsp100 family, mitochondrial homolog of Hsp104, protein refolding | Clp/Hsp100 |
| HSP26 | ↑2.9 | Small molecular chaperone | |
| AHA1 | ↑2.6 | Co-chaperone, binds Hsp82, activates Hsp90, similar to Hch1 | AHSA1 |
| HCH1 | ↑2.6 | Co-chaperone, binds and activates Hsp90 | |
| APJ1 | ↑2.4 | HSP40 (DNAJ) family, regulates Hsp70 activity, genetically interacts with Ydj1 | Contains a DNAJ domain |
| HSP42 | ↑2.3 | Small molecular chaperone | |
| CPR6 | ↑2.3 | Binds Hsp82, protein refolding | PPID |
| CIN1 | ↑2.1 | Tubulin-folding factor | TBCD |
| HSP31 | ↑1.9 | DJ-1/Pfpl family, amino acid substitution in DJ-1 associated with early-onset Parkinson's | DJ-1 |
| YDJ1 | ↑1.8 | Hsp40 (DNAJ), Ssa1 co-chaperone, regulates Hsp70 and Hsp90 functions, nascent chain folding, protein refolding | DNAJA2 (DNAJ [Hsp40]) |
| HSP60 | ↑1.6 | Mitochondrial chaperonin, nascent chain folding, protein refolding | HSPD1 |
| HSP10 | ↑1.5 | Hsp60 co-chaperonin, protein refolding | HSPE1 |
| MPD1 | ↓1.9 | Endoplasmic reticulum chaperone for glycoproteins | |
| SBA1 | ↓1.5 | Co-chaperone, binds to and regulates Hsp90 family, regulates telomerase activity | p23 |
Essential genes are underlined.