Fig. 7.

Dendritic Ca²⁺ spikes generated using different Ca²⁺ buffering models (aligned at the peak of the first spikelet in a, b, and f). The parameters of pool-based models are those used in Supplementary Fig. 1. The conductance values used to generate these spikes are listed in Table 2. a First burst of Ca²⁺ spikes. b Burst of Ca²⁺ spikes around 57 s. c, d Spontaneous Ca²⁺ spike bursting over 100 s: black asterisk indicates the first burst of Ca²⁺ spikes (shown in a), red asterisk indicates the burst of Ca²⁺ spikes around 57 s (shown in b). e Inter-burst interval (IBI) as a function of current injection. f Burst of Ca²⁺ spikes around 57 s with injection of 0.004 pA current