Table 1.
Detailed Ca2+ dynamics model parameters
| Parameter | Value | Reference |
|---|---|---|
| [Ca2+] at rest | 45 nM | [43] |
| [Mg2+] at rest | 590 μM | [25] |
| Diffusion rates | ||
| DCa | 0.233 μm2/ms | [44] |
| DCB | 0.028 μm2/ms | [25] |
| DPV | 0.043 μm2/ms | [25] |
| Calbindin | ||
| Concentration | 0.16 mM | –a |
| k on,fast | 43.5 ms−1 mM−1 | [45] |
| k off,fast | 3.58 × 10−2 ms−1 | [45] |
| k on,slow | 5.5 ms−1 mM−1 | [45] |
| k off,slow | 0.26 × 10−2 ms−1 | [45] |
| Parvalbumin | ||
| Concentration | 0.08 mM | –a |
| k on,Ca | 107 ms−1 mM−1 | [25] |
| k off,Ca | 9.5 × 10−4 ms−1 | [46] |
| k on,Mg | 0.8 ms−1 mM−1 | [25] |
| k off,Mg | 2.5 × 10−2 ms−1 | [46] |
| Pump | ||
| Density | 1 × 10−9 mol cm−2 | Estimated |
| k on | 3 × 10−3 ms−1 mM−1 | Estimated |
| k off | 1.75 × 10−5 ms−1 | Estimated |
| k ext | 7.255 × 10−5 ms−1 mM−1 | Estimated |
| Fraction of immobile calbindin | 0.2 | [25] |
aData provided by Dr. Klaus M. Stiefel, personal communication