Fig. 2.

High-resolution clinical PET/CT images of tumour-bearing mice imaged in a group of three. a, b Representative PET coronal slices in mice bearing subcutaneous tumours (a) or ovarian tumours (b) displaying heterogeneous ¹⁸F-FDG uptake are shown. c, d Corresponding CT coronal slices. e Linear regression between PET quantitative data (pooled data from Aide et al. [14, 23], including 33 organs and 22 tumours) and ex vivo counting shows an excellent correlation with a slope almost equal to unity. The PET data were reconstructed with an iterative algorithm that models the PSF of the PET system