Fig. 7.

Technological improvements that could benefit high-throughput PET imaging. a A tumour-bearing mouse imaged in a group of four animals in the customized bed shown in Fig. 3. Animals received intravenous and intraperitoneal injections of iodinated contrast medium. Images were reconstructed with FBP and MAP reconstruction, an algorithm that models the PSF of the system. Images are scaled to the same maximum. Note the artefacts near the bladder on the FBP images, which hamper the detection of a necrotic tumour also located near the bladder. These artefacts are not present on the MAP images. b Mice imaged using ⁶¹Cu-PTSM. Relative to that obtained with FBP, improved image resolution was achieved by the use of MAP reconstruction with PSF and positron range modelling (MAPR). With MAPR, the renal cortex can be resolved clearly in the kidney. b reprinted with permission of the Society of Nuclear Medicine from de Kemp et al. [19]