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Performance in T-maze was not affected by treatment with CGP55845. The baseline rate of spontaneous alternations was greater in 2N versus Ts65Dn mice. Acute and chronic treatment with CGP55845 had no effect on the alternation rate. Groups 2N-1 and Ts-1 were treated during the acute and chronic phase with the vehicle, Groups 2N-2 and Ts-2 with CGP55845. *p < 0.01 for all 2N versus Ts65Dn groups.
