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. 2012 Jul 4;32(27):9217–9227. doi: 10.1523/JNEUROSCI.1673-12.2012

Figure 7.

Figure 7.

Suppression of GABAB receptors increased tetanus-evoked fEPSPs. A, Examples of tetanus-evoked field responses during application of vehicle or CGP52432 (1 μm) in 2N (left) and Ts65Dn (right) slices. Horizontal lines on top mark the time of the tetani. Downward triangles indicate each 10's pulse of the tetanization train. Stimulus artifacts are truncated. B, Averaged amplitudes of responses to each 10 consecutive pulses of a 50-pulse tetanization (marked by horizontal line in A) normalized to the averaged amplitude of first 10 responses (1–10) at baseline conditions. Responses evoked during application of vehicle were smaller in Ts65Dn slices at the end of the 50-pulse train (pulses 20–50, white vs black). Application of CGP enhanced the responses in both 2N and Ts65Dn slices and abolished the difference between 2N and Ts65Dn slices (light gray vs dark gray). +p < 0.05, 2N Veh versus Ts65Dn Veh; *p < 0.01, Veh versus CGP for 2N or Ts65Dn slices.