FIG. 4.
Cytochrome c-dependent S-nitrosothiol formation. Ferric cytochrome c weakly binds glutathione, and this complex reacts with NO to form GSNO and ferrous cytochrome c. The process becomes catalytic if the cytochrome c is further oxidized by, for example, mitochondrial complex IV. (To see this illustration in color the reader is referred to the web version of this article at www.liebertpub.com/ars).