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. 2012 Oct 1;17(7):969–980. doi: 10.1089/ars.2012.4590

FIG. 4.

FIG. 4.

Cytochrome c-dependent S-nitrosothiol formation. Ferric cytochrome c weakly binds glutathione, and this complex reacts with NO to form GSNO and ferrous cytochrome c. The process becomes catalytic if the cytochrome c is further oxidized by, for example, mitochondrial complex IV. (To see this illustration in color the reader is referred to the web version of this article at www.liebertpub.com/ars).