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. 2011 Dec 5;21(12):2239–2251. doi: 10.1089/scd.2011.0607

FIG. 1.

FIG. 1.

Helios is expressed in specific brain areas during central nervous system development. Helios immunohistochemistry was performed in mouse brain coronal sections at E16.5 and P15. Representative fluorescent photomicrographs corresponding to anterior and posterior sections at E16.5 show Helios expression in: (A) the granular layer of accessory olfactory bulb from the anterior (A1, A2; note that A2 is a high magnification of A1) to the posterior axis (A3, A4; A4 represents the inset in A3); (B) the lateral ganglionic eminence (LGE), the cingulate (Cing) and insular (Ins) cortex; and (C) the retrosplenial cortex (Rs) and CA1/2 layer (CA1/2) of the hippocampus (C1, C2; C2 represents the inset in C1). (D) Helios is expressed by Purkinje neurons in the cerebellum at P15 (D1; D2 represents the inset in D1). Scale bars: (A) 1 mm; and (C, D) 2 mm.