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Helios and Ikaros are not expressed in the same LGE cells at E18.5. Double immunohistochemistry for Helios and Ikaros performed in the LGE at E18.5 shows a lack of coincidence between these two transcription factors (A). Note that Helios is expressed in the SVZ and MZ whereas Ikaros is only expressed in the MZ (A). Immunohistochemistry for Ikaros in wt and Helios–/– mice (He–/–) demonstrate no changes in Ikaros expression in the absence of Helios (B). Scale bars: (A) 400 μm; (B) 500 μm.
