Table 1.
Characteristics of case–control studies of hepatitis viruses infection and ICC risk
| First author | Year | Country |
Cases (n) |
Control (n) |
Control description |
OR (95% CI) for HBV infection |
OR (95% CI) for HCV infection |
Study quality |
|---|---|---|---|---|---|---|---|---|
| Parkin |
1991 |
Thailand |
100 |
100 |
Hospital-based control |
1.0 (0.4-2.1) |
– |
1 |
| Shin |
1996 |
Korea |
41 |
406 |
Hospital-based control |
1.3 (0.3-5.3) |
3.9 (0.9-17.1) |
2 |
| Donato |
2001 |
Italy |
26 |
824 |
Hospital-based control |
2.7 (0.4-18.5) |
9.7 (1.6-58.9) |
2 |
| Yamamoto |
2004 |
Japan |
50 |
205 |
Hospital-based control |
1.8 (0.3-10.1) |
16.8 (5.7-50.0) |
2 |
| Shaib |
2005 |
US |
625 |
90834 |
Population-based control |
0.8 (0.1-5.9) |
6.1 (4.3-8.6) |
2 |
| Choi |
2006 |
Korea |
185 |
185 |
Hospital-based control |
0.8 (0.198-3.023) |
1.0(0.04-25.264) |
2 |
| Shaib |
2007 |
US |
83 |
236 |
Hospital-based control |
2.9 (0.1-236.8) |
7.9 (1.3-84.5) |
2 |
| Welzel |
2007 |
US |
535 |
102782 |
Population based control |
– |
4.4 (1.4-14.0) |
1 |
| Lee |
2008 |
Korea |
622 |
2488 |
Hospital-based control |
2.3 (1.6-3.3) |
1.0 (0.5-1.9) |
2 |
| Zhou |
2008 |
China |
312 |
438 |
Hospital-based control |
8.876 (5.98-13.19) |
0.933 (0.281-3.1) |
2 |
| Lee |
2009 |
Taiwan |
160 |
160 |
Hospital-based control |
4.985 (2.78-8.95) |
2.71 (1.16-6.32) |
2 |
| Tao |
2010 |
China |
61 |
380 |
Hospital-based control |
18.1 (7.5-44.0) |
– |
1 |
| Peng | 2011 | China | 98 | 196 | Hospital-based control | 2.75 (1.27-5.95) | – | 1 |
ICC, intrahepatic cholangiocarcinoma; HBV,hepatitis B virus; HCV, hepatitis C virus; US, United States.