Table 1.

Comparison of insulin degludec and other insulin analogs.

Basal insulin	Onset	Peak	Duration	Comments
NPH	1–2 hours	4–8 hours	8–12 hours	Greatest risk for hypoglycemia
Glargine	30–60 minutes	No peak	16–24 hours	– Greatest potential for weight gain. – Possible mitogenicity
Detemir	30–60 minutes	No peak	16–24 hours	May need twice daily injections.
Degludec	30–90 minutes	No peak	Over 24 hours	– Least risk of hypoglycemia – No mitogenicity
Degludec plus	5–15 minutes	30–60 minutes	Over 24 hours	Same as degludec with advantage of added prandial coverage.

Abbreviation: NPH, neutral protamine hagedorn.