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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Neurobiol Aging. 2010 May 5;33(3):555–563. doi: 10.1016/j.neurobiolaging.2010.04.003

Fig. 4.

Fig. 4

Hippocampal brain-derived neurotrophic factor (BDNF) messenger ribonucleic acid (mRNA) levels measured by absolute quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR). At 6 weeks of age (A), TgCRND8 mice (n = 5) had reduced BDNF mRNA levels in the hippocampus compared with nontransgenic (non-Tg) mice (n = 4). However at 9 weeks (B), there was no significant difference between TgCRND8 mice (n = 7) and non-Tg littermates (n = 9). By 6 – 8 months (C), hippocampal BDNF mRNA was reduced in TgCRND8 mice (n = 4) in comparison with littermate controls (n = 4). Data are expressed as a ratio of copies of BDNF mRNA/copies of β-actin mRNA. Values are means ± standard error of the mean (SEM). *p < 0.05 by unpaired Student t test.