Figure 2. Comparison of proportion responders in human and bovine hosts with active TB.

Responses to 28 PE/PPE peptide pools were assessed in both cattle and humans with active TB, by Bovigam or ELISPOT assays. Individual cattle samples were scored as positive if ΔOD₄₅₀ values were ≥0.1, and human samples were scored as positive if ≥20 SFC were counted per 10⁶ PBMC. Linear regression analysis produced the line shown. A Pearson correlation test revealed a statistically significant correlation between the proportion human responders and the proportion bovine responders; r(26)  = 0.539, 2-tailed p value  = 0.0031.