Figure 6. Whole blood IFN-Υ responses to individual and pooled PE/PPE peptides.

Peptide pools eliciting positive responses were further analysed by assessing the contribution of each constituent peptide at 3, 5 or 9 weeks post-infection. Representative data are shown for peptides corresponding to (A) One pool derived from PE8, and (B) One pool derived from PPE15. The solid lines represent the temporal response to a peptide pool, while individual symbols correspond to individual peptides. (C) and (D) BLASTP homology searches were performed with peptides which elicited positive responses, and closest matches are shown in a CLUSTALW alignment.