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. 2012 Aug 1;7(8):e41976. doi: 10.1371/journal.pone.0041976

Figure 4. Absence of survivin in beta cells leads to glucose intolerance after PDL.

Figure 4

(a) At PDL day 7, female RIPCre+Survivinfl/flmice exhibit markedly higher glucose excursions during an IPGTT compared with other groups (n = 10 per genotype). (b) In vivo GSIS after i.p. glucose injection is markedly compromised in the mutant mice compared with that in other groups (n = 10 per genotype). ▪, RIPCre+Survivin+/+ sham day 7; □, RIPCre+Survivinfl/fl sham day 7; ▴, RIPCre+Survivin+/+ PDL day 7; △, RIPCre+Survivinfl/fl PDL day 7. The data represent as means ± SE. *, p<0.05 vs sham operation.