Figure 8. Insula activity predicts magnitude of airway obstruction and cognitive interference of disease-related information during the late phase response to Ag.

Percent signal change in the right mid- and posterior insula in response to asthma compared to negative words [As-Ng] and (a) percent peak fall in FEV₁ [Ag-Meth] (r = −.59, p = .001) and (b) reaction time to identify the color of As words, relative to Ng words [Ag(As-Ng)-Meth(As-Ng)] (r = .66, p<.001) during late phase antigen relative to methacholine challenge. Coordinates are in MNI space.