Figure 2. 3xTg-AD/BDNF^+/− and 3xTg-AD/BDNF^+/+ mice have comparable levels of Aβ and tau pathology.

No differences between groups were detected by ELISA in levels of Aβ_1–40 or Aβ_1–42 in soluble (A, n = 4) or insoluble (B, n = 4) fractions. (C) Representative maximum intensity projections of immunofluorescently labeled Aβ and tau in CA1 and cortex indicate a similar pattern of immunoreactivity between 3xTg-AD/BDNF^+/+ and 3xTg-AD/BDNF^+/− mice. Scale bars  = 20 μm. Western blot analyses suggest 3xTg-AD/BDNF^+/+ and 3xTg-AD/BDNF^+/− mice have similar levels of proteins related to Aβ production (D–E, n = 6) and similar levels of tau and various tau phospho-epitopes (F–G, n = 6). Data are presented as means ±SEM.