Table 4. Incidence Rate Ratios for Mixed Anxiety and Depression.

Variable		No of Events	PYAR	Incidence(95% CI)	Univariable* IRR(95% CI)	P-value+	Multivariable* ∧ IRR(95% CI)	P-value+
Year	1998	3537	883306	4.0 (3.9,4.1)	Baseline	<0.0001	Baseline	<0.0001
	1999	4850	1146749	4.2 (4.1,4.4)	1.06 (0.93,1.20)		1.06 (0.93,1.21)
	2000	6825	1503518	4.5 (4.4,4.6)	1.13 (0.97,1.32)		1.14 (0.98,1.33)
	2001	7939	1780650	4.5 (4.4,4.6)	1.11 (0.96,1.29)		1.13 (0.97,1.31)
	2002	8617	2064236	4.2 (4.1,4.3)	1.04 (0.89,1.23)		1.05 (0.89,1.24)
	2003	9031	2295956	3.9 (3.9,4.0)	0.98 (0.83,1.17)		0.99 (0.83,1.18)
	2004	8683	2444601	3.6 (3.5,3.6)	0.89 (0.74,1.06)		0.89 (0.75,1.06)
	2005	8111	2604062	3.1 (3.1,3.2)	0.78 (0.65,0.93)		0.79 (0.66,0.94)
	2006	7495	2723743	2.8 (2.7,2.8)	0.69 (0.56,0.84)		0.69 (0.57,0.84)
	2007	6879	2774830	2.5 (2.4,2.5)	0.62 (0.49,0.78)		0.62 (0.50,0.77)
	2008	2888	1305137	2.2 (2.1,2.3)	0.55 (0.44,0.69)		0.56 (0.45,0.68)
	TOTAL	74855	21526788	3.5 (3.5,3.5)
Gender	Male	24191	10357374	2.3 (2.3,2.4)	Baseline	<0.0001	Baseline	<0.0001
	Female	50664	11169414	4.5 (4.5,4.6)	1.94 (1.88,2.01)		2.01 (1.95,2.08)
Age group	16 to 24	6389	2743476	2.3 (2.3,2.4)	Baseline	<0.0001	Baseline	<0.0001
	25 to 44	32558	7883564	4.1 (4.1,4.2)	1.77 (1.69,1.87)		1.80 (1.71,1.90)
	45 to 64	25340	6347288	4.0 (3.9,4.0)	1.71 (1.60,1.83)		1.78 (1.67,1.89)
	65 to 74	5643	2242792	2.5 (2.5,2.6)	1.08 (0.99,1.18)		1.09 (1.01,1.17)
	75+	4925	2309669	2.1 (2.1,2.2)	0.92 (0.83,1.02)		0.88 (0.80,0.97)
Deprivation	Missing	3023	1803736	1.7 (1.6,1.7)	Excluded		Excluded
(Least Deprived)	Q1	15494	5086918	3.0 (3.0,3.1)	Baseline	<0.0001	Baseline	<0.0001
	Q2	13901	4439284	3.1 (3.1,3.2)	1.03 (0.92,1.14)		1.04 (0.94,1.16)
	Q3	14492	4162459	3.5 (3.4,3.5)	1.14 (1.01,1.30)		1.17 (1.03,1.32)
	Q4	15109	3619361	4.2 (4.1,4.2)	1.37 (1.17,1.60)		1.41 (1.21,1.65)
(Most Deprived)	Q5	12836	2415030	5.3 (5.2,5.4)	1.75 (1.43,2.13)		1.82 (1.50,2.21)

^*Standard Errors Adjusted For Practice;

⁺P-value based on Wald test.

^∧Mutually adjusted for period, gender, age and deprivation and for clustering by practice using robust standard errors.