Table 2. A. Body weight during the treatment.

A	BW (g)
Treatment	Day 1	Day 12	Day 19	Day 26	Day 33	Day 40	Day 47	Day 54	Day 61
Lean Veh	35.8±0.3*	35.2±0.4*	35.5±0.4*	36.1±0.4*	36.0±0.4*	36.0±0.5*	35.5±0.4*	37.4±0.3*	36.3±0.4*
DIO Veh	46.9±1.0	46.8±1.0	46.6±1.6	48.0±1.1	47.6±1.1	49.9±1.1	49.9±0.9	52.0±0.8	51.2±0.9
CB1 ASO 25mg/kg/wk	47.3±0.9	47.5±0.9	47.6±0.9	47.1±1.0	46.5±1.0	46.6±0.8*	45.9±1.0*	47.3±0.9*	46.1±1.0*
CB1 ASO 12.5mg/kg/wk	47.9±1.2	47.9±1.3	48.0±1.3	48.2±1.4	48.0±1.5	48.2±1.7	48.3±1.6	50.4±1.5	49.4±1.4
CB1 ASO 6.25mg/kg/wk	47.6±1.1	47.4±1.3	48.6±1.1	48.6±1.1	48.9±1.2	49.2±1.2	49.2±1.1	50.9±1.2	49.1±1.3
Control ASO 25mg/kg/wk	47.3±1.0	47.3±1.0	47.8±1.0	48.4±1.1	48.8±1.2	49.3±1.2	49.9±1.2	51.9±1.2	50.5±1.3
B	BW (% of starting)
Treatment	Day 1	Day 12	Day 19	Day 26	Day 33	Day 40	Day 47	Day 54	Day 61
DIO Veh	100±2.2	99.9±2.0	99.4±3.5	102.4±2.4	101.4±2.4	106.5±2.2	106.5±1.8	111.0±1.8	109.2±1.9
CB1 ASO 25mg/kg/wk	100±1.8	100.4±1.9	100.7±1.9	99.5±2.1 *	98.3±2.0*	98.5±1.7*	97.0±2.1 *	100.1±2.0*	97.6±2.0*
CB1 ASO 12.5mg/kg/wk	100±2.5	100±2.7	100.1±2.7	100.6±2.9	100.0±3.1	100.5±3.5	100.7±3.4	105.0±±3.2	102.9±2.9
CB1 ASO 6.25mg/kg/wk	100±2.4	99.5±2.8	100.2±2.2	102.1±2.4	102.6±2.5	103.4±2.4	103.3±2.4	106.9±2.4	103.3±2.8
Control ASO 25mg/kg/wk	100±2.0	100±2.1	101.0±2.1	102.3±2.3	103.2±2.5	104.3±2.5	105.4±2.6	109.8±2.5	106.8±2.7

B. Body weight change (% of the beginning body weight) during the treatment. One way ANOVA Dunnett’s multiple test compared to DIO Veh, *p<0.05.