Table 6. Liver, spleen and epididymal fat weights, liver TG and plasma total PAI-1 at the end of treatment.
Treatment | Liver weight (g) | Liver TG (mg/g tissue) | Epididymal fat (g) | Spleen weight (g) | Plasma total PAI-1(pg/mL) |
Lean Veh | 1.82±0.05* | 15±1* | 1.17±0.07* | 0.080±0.007 | 837±93* |
DIO Veh | 2.39±0.16 | 87±5 | 2.17±0.21 | 0.087±0.004 | 1722±244 |
CB1R ASO25 mg/kg/wk | 1.97±0.09* | 40±6* | 1.99±0.16 | 0.138±0.009* | 2765±327* |
CB1R ASO12.5 mg/kg/wk | 2.26±0.12 | 71±8 | 1.94±0.22 | 0.121±0.024 | 2145±278 |
CB1R ASO6.25 mg/kg/wk | 2.21±0.10 | 81±12 | 2.08±0.15 | 0.093±0.003 | 1357±96 |
Control ASO25 mg/kg/wk | 2.06±0.11 | 69±4 | 2.18±0.13 | 0.076±0.004 | 1180±83 |
Values shown are mean ± se. One way ANOVA Dunnett’s multiple test compared to DIO Veh, *p<0.05.