Table 7. mRNA levels of several genes in epididymal fat and liver at the end of the study.
Tissue | Gene | DIO Veh | CB1R ASO25 mg/kg/week | CB1R ASO12.5 mg/kg/week | CB1R ASO6.25 mg/kg/week | Control ASO25 mg/kg/week |
Liver | SREBP-1 | 1.02±0.06 | 0.74±0.06* | 0.73±0.08* | 0.90±0.05 | 0.95±0.11 |
Liver | G6PC | 1.15±0.23 | 0.43±0.09* | 0.68±0.13 | 0.91±0.13 | 0.99±0.13 |
Liver | CD36 | 1.20±0.30 | 0.20±0.02* | 0.44±0.10* | 0.86±0.13 | 0.53±0.13 |
Epididymal fat | SREBP-1 | 1.03±0.10 | 0.57±0.11* | 0.73±0.13 | 0.83±0.15 | 0.75±0.13 |
Values shown are mean ± se. Student t- test, compared to DIO Veh, *p<0.05.