Table 1. Renal function at 1 year and 5 years of age in intact female sham and uni-x sheep.
| sham | Uni-x | P-value | |||
| Age (years) | 1 year | 5 years | 1 year | 5 years | |
| Plasma sodium (mmol) | 144±1 | 143±1 | 143±1 | 143±1 | Ptreatment = 0.3 Page = 0.3 Ptreatment × age = 0.5 |
| UFR (ml/kg/h) | 2.0±0.4 | 0.8±0.2 | 1.8±0.5 | 0.9±0.2 | Ptreatment = 0.8 Page = 0.002 Ptreatment × age = 0.9 |
| UNaV (µmol/kg/h) | 109±64 | 192±64 | 87±49 | 79±23 | Ptreatment = 0.2 Page = 0.2 Ptreatment × age = 0.4 |
| Filtered load of sodium(mmol/kg/h) | 17.4±1.0 | 17.3±0.2 | 11.1±0.3 | 9.7±0.1 | Ptreatment<0.001 Page = 0.4 Ptreatment × age = 0.5 |
| FENa % | 1.5±0.4 | 1.3±0.3 | 0.8±0.4 | 1.0±0.2 | Ptreatment = 0.1 Page = 0.4 Ptreatment × age = 0.5 |
| GFR (ml/kg/h) | 121±6 | 125±2 | 78±2 | 69±8 | Ptreatment<0.001 Page = 0.8 Ptreatment × age = 0.3 |
| RBF (ml/kg/h) | 883±113 | 826±38 | 936±142 | 492±13 | Ptreatment = 0.2 Page = 0.017 Ptreatment × age = 0.046 |
| Filtration fraction (%) | 15.2±0.8 | 20.9±0.9 | 8.4±1.2 | 19.0±2.1 | Ptreatment = 0.03 Page = 0.002 Ptreatment × age = 0.06 |
| RVR (mmHg/ml/kg/h) | 0.10±0.02 | 0.10±0.02 | 0.10±0.01 | 0.21±0.01 | Ptreatment = 0.008 Page<0.001 Ptreatment × age = 0.001 |
UFR; urine flow rate, UNaV; Urinary sodium excretion, FENa %; fractional excretion of sodium, GFR; glomerular filtration rate, RBF; renal blood flow, RVR; renal vascular resistance. Values are mean ± SEM, from a two-way repeated ANOVA. n = 5 per treatment group per age.