Table 2. Echocardiography results at 2 and 5 years of age in sham and uni-x animals.

	2 years		5 years
Females	sham	uni-x	sham	uni-x	P-value
LVEDd (cm)	3.33±0.03	3.47±0.23	3.31±0.12	4.05±0.19	Ptreatment<0.0001 Page = 0.002 Ptreatment × age = 0.001
PWTd (cm)	0.78±0.01	0.82±0.04	0.72±0.09	1.01±0.11	Ptreatment<0.001 Page = 0.06 Ptreatment × age<0.0001
IVSDd (cm)	0.93±0.03	0.97±0.05	1.01±0.11	1.20±0.09	Ptreatment = 0.07 Page = 0.0005 Ptreatment × age = 0.006
LV mass (g)	112.1±2.6	118.1±10.8	109.7±10.92	173.1±25.0	Ptreatment<0.001 Page<0.001 Ptreatment × age<0.001
LV mass indexed (g/kg)	1.85±0.07	1.82±0.17	1.96±0.28	3.35±1.01	Ptreatment = 0.001 Page<0.001 Ptreatment × age = 0.001
Fractional shortening (%)	32.09±4.06	30.88±3.34	34.3±3.3	26.7±4.8	Ptreatment = 0.08 Page<0.57 Ptreatment × age = 0.02

LVEDd, left ventricular diameter in diastole; PWTd, posterior wall thickness in diastole; IVSDd, interventricular septum in diastole. LV, left ventricular mass; LV mass indexed, left ventricular mass corrected for body weight. Values are from two-way repeated ANOVA and expressed as mean ± SEM. n = 5 per treatment group per age.