Table 3. Comparison of effect sizes of CEU-identified variants for CRC across CEU and three different Chinese populations.
| CEU# | NCH? | HK-CH& | SCH | |||||
| Chr | iSNP | OR (95% CI) | iSNP | OR (95% CI) | iSNP/sSNP | OR (95% CI) | iSNP/sSNP | OR (95% CI) |
| 1q41 | rs6687758 | 1.09 (1.06, 1.12)* | rs6695584 | 1.16 (0.98, 1.36)* | ||||
| 3q26.2 | rs10936599 | 0.93 (0.91, 0.96)* | rs12638862 | 0.98 (0.87, 1.12) | ||||
| 8q23.3 | rs16892766 | 1.25 (1.19, 1.32)* | rs16892766 | NP | rs11986063 | 1.40 (1.04, 1.89)* | ||
| 8q24.21 | rs6983267 | 1.27 (1.16, 1.39)* | rs6983267 | 1.23 (1.13–1.34)* | rs7014346 | 1.23 (1.05–1.44)* | rs6983267 | 1.15 (1.00, 1.31)* |
| 10p14 | rs10795668 | 0.89 (0.86, 0.91)* | rs10795668 | 1.23 (1.12–1.34)** | rs10795668 | 1.28 (1.1–1.5)* | rs827401 | 0.74 (0.63, 0.88)** |
| 11q23.1 | rs3802842 | 1.11 (1.08, 1.15)* | rs3802842 | 1.29 (1.18–1.40)* | rs3802842 | 1.10 (0.95–1.27) | rs3087967 | 1.22 (1.07, 1.38)* |
| 12q13.13 | rs7136702 | 1.06 (1.04–1.08)* | rs7136702 | 1.08 (0.95, 1.22) | ||||
| 14q22 | rs4444235 | 1.11 (1.08–1.15)* | rs4444235 | 1.08 (0.99–1.18) | rs4444235 | 1.02 (0.88–1.18) | rs4444235 | NS |
| 15q13.3 | rs4779584 | 1.23 (1.14, 1.34)* | rs4779584 | 1.02 (0.92–1.13) | rs4779584 | 1.26 (1.04–1.52)* | rs4779584 | 1.14 (0.94, 1.38) |
| 16q22.1 | rs9929218 | 0.91 (0.89, 0.94)* | rs9929218 | 1.09 (0.97–1.23) | rs9929218 | 1.00 (0.84–1.18) | rs2059254 | 0.86 (0.73, 1.00)* |
| 18q21.1 | rs4939827 | 1.18 (1.12, 1.23)* | rs4939827 | 1.17 (1.05–1.31)* | rs4939827 | 1.17 (1.01–1.37)* | rs7226855 | 1.13 (0.99, 1.28)* |
| 19q13.1 | rs10411210 | 1.15 (1.10–1.20)* | rs10411210 | 1.10 (0.99–1.22) | rs10411210 | 1.02 (0.85–1.24) | rs10411210 | NS |
| 20p12.3 | rs961253 | 1.12 (1.08, 1.16)* | rs961253 | 1.37 (1.19–1.59)* | rs355527 | 1.10 (0.84–1.45) | rs5005940 | 1.00 (0.79, 1.28) |
| 20q13.33 | rs4925386 | 0.93 (0.91,0.95)* | rs4925386 | NS | ||||
#
CEU SNP reference sources: as reported in the GWAS catalogue for CRC: http://www.genome.gov/gwastudies/index.cfm?pageid=26525384#searchForm.
?Northern Chinese (reference 5); &Hong Kong Chinese (reference 6); NP = non-polymorphic; NS = no surrogate SNP at high LD within 100 kb of iSNP; empty cell = SNP not interrogated; *show evidence of being associated with CRC risk; **show evidence of being associated with rectal cancer risk.