Table 6. Rates of ocular adverse effects of RCTs evaluating bevacizumab for indirect comparison and dose-relationship evaluation.
Study | Endophthalmitis (%) | Uveitis (%) | Retinal detachment (%) | Retinal tear (%) | Lens damage (traumatic) (%) | Vitreous haemorrhage (%) | ||||||
1.0 mg | PDT+T | 1.0 mg | PDT+T | 1.0 mg | PDT+T | 1.0 mg | PDT+T | 1.0 mg | PDT+T | 1.0 mg | PDT+T | |
Sacu et al. 2009 [26] | 0.0 | 0.0 | 0.0 | 0.7 | 1.5 | 0.0 | 0.0 | 0.7 | 0.0 | 0.0 | 1.5 | 0.0 |
1.25 mg | PDT+B | 1.25 mg | PDT+B | 1.25 mg | PDT+B | 1.25 mg | PDT+B | 1.25 mg | PDT+B | 1.25 mg | PDT+B | |
Costagliola et al. 2010 [27] | nr | nr | nr | nr | nr | nr | nr | nr | nr | nr | nr | nr |
1.25 mg | UC | 1.25 mg | UC | 1.25 mg | UC | 1.25 mg | UC | 1.25 mg | UC | 1.25 mg | UC | |
ABC trial 2010 [28] | 0.0 | 0.0 | 3.0 | 2.0 | 0.0 | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.0 |
B: Bevacizumab. Nr: Not reported. T: Triamcinolone. UC: Usual care.