Table 3. Top 5 canonical signalling pathways associated with each gene expression cluster.
| Cluster ID | Canonical Pathway | p-value* |
| Cluster 1 | Chemokine signaling | 1.7E-04 |
| G-protein coupled receptor signaling | 1.06E-03 | |
| CCR3 signalling in eosinophils | 2.36E-03 | |
| Pentose phosphate pathway | 6.14E-03 | |
| Nicotinate and nicotinamide metabolism | 6.21E-03 | |
| Cluster 2 | Calcium signaling | 1.7E-04 |
| Gonadotrophin releasing hormone (GNRH) signaling | 1.43E-03 | |
| Integrin signaling | 2.17E-03 | |
| Tight junction signaling | 4.01E-03 | |
| Glycerophospholipid metabolism | 7.94E-03 | |
| Cluster 3 | DNA-double strand break repair by homologous recombination | 1.62E-06 |
| Role of BRCA1 in DNA damage response | 3.14E-05 | |
| Hereditary breast cancer signaling | 1.16E-04 | |
| Purine metabolism | 1.74E-03 | |
| Role of NFAT in cardiac hypertrophy | 6.48E-03 | |
| Cluster 4 | Metabolism of xenobiotics by Cytochrome P450 | 1.69-02 |
| Fatty acid metabolism | 1.89E-02 | |
| Tryptophan metabolism | 2.1E-02 | |
| Extrinsic prothrombin activation pathway | 2.75E-02 | |
| Ascorbate and aldarate metabolism | 3.09E-02 | |
| Cluster 5 | Role of IL17A in psoriasis | 1.51E-04 |
| Hepatic fibrosis/hepatic stellate cell activation | 1E-03 | |
| NF-kB signaling | 1.67E-03 | |
| Role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis | 3.59E-03 | |
| Growth hormone signaling | 4.2E-03 | |
| Cluster 6 | Systemic lupus erythematosus signaling | 5.92E-02 |
*
p-value calculated using Fisher's exact test determining the probability that association between genes in the data set and canonical pathway is due to chance alone.