Table 4. Top gene networks and associated biological functions for gene expression clusters.

Cluster ID	Network ID	Associated Gene Network Functions	Score*
Cluster 1	1	Cellular development, cellular growth and proliferation	46
	2	Inflammatory response, cell signalling and inflammatory disease	38
	3	Lipid metabolism, small molecule biochemistry and ophthalmic disease	38
	4	Connective tissue disorders, dental disease, developmental disorder	33
	5	Connective tissue disorders, genetic disorder, skeletal and muscular disorders	28
Cluster 2	1	Cellular assembly and organisation, cellular function and maintenance	46
	2	Cellular assembly and organization, skeletal and muscular system development and function	43
	3	Cellular development, cellular growth and proliferation, connective tissue development and function	22
	4	Cardiovascular system development and function, organ development, molecular transport	22
	5	Cardiovascular disease, cell death, gastrointestinal disease	22
Cluster 3	1	Lipid metabolism, small molecule biochemistry, molecular transport	41
	2	Cell cycle, DNA replication, recombination and repair, cellular assembly and organization	33
	3	Connective tissue disorders, genetic disorder, ophthalmic disease	26
	4	Developmental disorder, genetic disorder, neurological disease	22
	5	RNA post-translational modification, cell cycle, haematological system development and function	22
Cluster 4	1	Cellular development, inflammatory response, cellular growth and proliferation	33
	2	Gene expression, cardiovascular system development and function, cell morphology	31
Cluster 5	1	Cellular movement, haematopoiesis, immune cell trafficking	33
	2	Cardiovascular system development and function, organismal development	20
Cluster 6	1	Cellular growth and proliferation, cellular development, haematological system development	14

^*Gene network score is a numerical value used to rank networks according to how relevant they are to the genes in the input dataset. IPA uses a right-tailed Fisher's test to calculate the p-value for networks. A score of 10 indicates a p = 10⁻¹⁰ chance that genes in that network are associated solely by chance. Only gene networks with a score >10 shown.