Figure 7. Improved anti-tumor responses in the absence of RORC.

Lethally irradiated B6D2 F1 mice were injected with 3 × 10⁶ TCD BM with or without 4 × 10⁶ WT B6D2 or RORC^−/− Tconv cells. Additionally all recipient mice received 1 × 10⁴ P815 cells with the BM inoculum. Survival was determined by Kaplan and Meier method. An improvement in overall survival was found in B6D2 F1 mice given RORC^−/− Tconv cells compared to B6D2 T cells or BM + P815 cells (p < 0.05). n=7 recipients receiving RORC null T cells, n=5 recipients receiving B6D2 T cells, n=4 recipients receiving BM. Data combined from 2 individual experiments.