Fig. 5.

Simulation of FoxP3 expression by NAC in lupus T cells. A) FoxP3 expression in CD4⁺/CD25⁺ and CD8⁺/CD25⁺ T cell subsets of lupus and control donors matched for age, gender, and ethnicity by flow cytometry. Red and blue values indicate percentage of FoxP3⁺ cells in lupus and control donors, respectively. B) Cumulative analysis of FoxP3 expression in CD25⁺ T-cell subsets in lupus subjects and matched controls. p values reflect comparison with two-tailed unpaired t-test. C) Effect of NAC on Foxp3 expression in CD25⁺ T cell subsets of lupus patients exposed to all doses considered together. p values reflect comparison with two-tailed paired t-test.