Table 1.

Numeric representation of the human IG repertoire analyzed from humanized NSG mice

Source	Human CD5−/CD5+ B cell subsets1	Number of cells sorted	Number of unique IG sequences			Number of scFv-Fc
			VH	Vκ	cognate VH-Vκ pair2
Bone marrow	Early Immature	72	60	49	44	31
	Immature	72	39	48	34	27
Peripheral blood	New Emigrant	96	50	51	42	36
	Mature	96	59	64	57	57
	Mature (CD5+)	72	49	52	42	25
Total		408	257	264	219	176

¹except the ‘Mature (CD5⁺)’ B cells that were sorted following gating on a CD19⁺CD5⁺ cell population, all the other human B cell subsets were sorted on a CD19⁺CD5⁻ gate (see Figure 1)

² inclusive of numbersindicated for individual V_H and V_κ sequences