. Author manuscript; available in PMC: 2013 Jan 1.

Published in final edited form as: Genes Immun. 2012 May 17;13(5):399–410. doi: 10.1038/gene.2012.16

Table 2.

Distribution of hypermutated V_H genes in hNSG mice

B cell subpopulations	Homology to germline sequence
	100–99%			99–94%			≤94%
	# (%) Sequences¹	nt/aa mutations²		# (%) Sequences	nt/aa mutations		# (%) Sequences	nt/aa mutations
	# (%) Sequences¹	FR	CDR	# (%) Sequences	FR	CDR	# (%) Sequences	FR	CDR
Early Immature	36 (60%)	0.46/0.32	0.07/0.05	20 (33%)	1.77/1.14	1.18/0.79	4 (7%)	0.44/0.23	0.53/0.30
Immature	26 (67%)	0.68/0.38	0.16/0.08	8 (21%)	0.97/0.57	0.51/0.32	5 (13%)	1.46/0.86	1.14/0.54
New Emigrant	33 (66%)	0.30/0.22	0.18/0.08	17 (34%)	1.56/1.14	1.14/0.72	0 (0%)	-	-
Mature	50 (85%)	0.60/0.38	0.17/0.10	9 (15%)	0.36/0.24	0.14/0.05	0 (0%)	-	-
Mature (CD5⁺)	41 (84%)	0.38/0.23	1.18/0.79	8 (16%)	0.68/0.49	0.47/0.30	0 (0%)	-	-

Total number and corresponding percentage (in parentheses) of total sequences per B cell subset

Total number of nucleotide/amino acid changes in the Framework region (FR) and H-CDR3 (CDR) regions per V_H sequence