Table 3.

Potential V_H replacement analysis of the human IG sequences from various B cell subsets¹

¹Nucleotide sequence nomenclature used in the table is from IMGT. The listed sequences start from the first nucleotide of the cryptic recombination signal sequence (indicated in upper case), through the V-D junction into the D_H region. The V_H donor family, D_H family, J_H family and Replacement (Recipient) family (R _Fam) designations are listed as well. The bold and underlined nucleotides and amino acids in the V-D (N1) region match the 3′-end of the V_H germline of the replacement family and the charged amino acids are shown in red. V_H replacement sequences represent 5% of the total number of Abs analyzed. Italics in the V_H donor column represent gene segments that are downstream to the recipient and thus correspond to a potential non-conventional V_H replacement process.