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EPC transplantation and BBB repair. Neurovascular repair is achieved via endogenous EPCs mobilized towards the ischemic brain, which can be enhanced by exogenous EPC delivery either from the periphery or direct intracerebral transplantation (Panel A). Following honing to the area of injured vasculature, the EPCs promote restoration of BBB, potentially affording anti-inflammatory effects then abrogating stroke-induced histopathological symptoms (Panel B).
