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. Author manuscript; available in PMC: 2013 Aug 15.
Published in final edited form as: J Immunol. 2012 Jul 11;189(4):1800–1811. doi: 10.4049/jimmunol.1200850

Figure 3. Comparison of allergen epitope induced IL-4, -5 and -13 responses.

Figure 3

An analysis of IL-4, IL-5 and IL-13 producing cells in representative donors in response to Alternaria and Rye Grass peptides. Responses to IL-4, -5 and -13 were measured in ELISPOT assays on day 14, as described in the Materials and Methods. In donor U00064 Alternaria peptides 11, 13, 14, 15, 16, and 17 induced IL-5, IL-4 and IL-13 responses. Additionally, IL-5 responses were induced by peptides 12, 66, 67, 68 and 70. Together, these data show that all epitopes inducing IL-4 and IL-13 responses also induced IL-5 responses. A similar pattern was noted in donor U00099 in response to Rye Grass peptides, where peptides 1168, 1175, 1181 and 1184 all induced IL-5 responses, and the same peptides encompassed all IL-4 and IL-13 responses.

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