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. 2012 Apr 16;109(31):E2134–E2143. doi: 10.1073/pnas.1109370109

Fig. 1.

Fig. 1.

Reciprocal regulation of NaV1.5 and Kir2.1 in ARVMs. (A and C) NaV1.5 overexpression increases both INa and IK1 densities. (A) Superimposed INa density/voltage relationships (5 mmol/L [Na+]o) for Ad-GFP– (black; N = 1, n = 7) and Ad-NaV1.5–infected (red; N = 2, n = 6) cells. (B) Voltage-dependent activation and inactivation (m∞ and h∞) curves for the data presented in A. (C) Superimposed IK1 density/voltage relationship for Ad-GFP– (black; N = 3, n = 8) and Ad-NaV1.5–infected (red; N = 3, n = 8) cells. (Inset) Magnification of the outward component of the IK1 I–V relationship. (D and E) Kir2.1 overexpression increases both IK1 and INa densities. (D) Superimposed IK1 density/voltage relationships for Ad-GFP (black; N = 3, n = 8) and Ad-Kir2.1 (red; N = 2, n = 5). (E) Superimposed INa density/voltage relationships (20 mmol/L [Na+]0) for Ad-GFP (black; N = 2, n = 6) and Ad-Kir2.1 (red; N = 4, n = 7). (F) Voltage-dependent activation and inactivation (m∞ and h∞) curves for the data presented in E. *P < 0.005; #P < 0.05; δP < 0.01 (unpaired t test with Welch’s correction). N represents the number of animals/litters, and n equals the number of experiments or cells.