Table 1.
Baseline characteristics in the overall study cohort and unadjusted hazard ratio of death at 30-days post-BAV.
| Overall (n = 281) | Unadjusted HR (95% CI) 30-day mortality | P value | |
|---|---|---|---|
| Male | 111 (39.2%) | 1.21 (0.63 – 2.33) | 0.57 |
| Age (years) | 83.0 ± 9.4 | 0.98 (0.95 – 1.02) | 0.32 |
| Additive EuroSCORE | 11.8 ± 3.8 | 1.09 (1.01 – 1.18) | 0.02 |
| Logistic EuroSCORE | 32.8 ± 22.6 | 1.02 (1.00 – 1.03) | 0.01 |
| BSA (m2) | 1.71 ± 0.24 | 0.87 (0.22 – 3.51) | 0.85 |
| Past medical history | |||
| Diabetes | 78 (27.6%) | 1.17 (0.58 – 2.38) | 0.67 |
| COPD | 48 (17.0%) | 0.58 (0.21 – 1.65) | 0.31 |
| PAD | 57 (20.1%) | 1.85 (0.91 – 3.76) | 0.09 |
| Stroke | 33 (11.7%) | 0.95 (0.34 – 2.68) | 0.92 |
| Prior CV surgery | 59 (20.9%) | 1.45 (0.70 – 3.00) | 0.32 |
| Renal dysfunction | 53 (18.7%) | 3.23 (1.65 – 6.32) | <0.001 |
| Hyperlipidemia | 155 (54.8%) | 0.67 (0.35 – 1.29) | 0.23 |
| Smoker | 33 (11.7%) | 0.41 (0.10 – 1.72) | 0.22 |
| LV function | 0.10 | ||
| Normal | 108 (38.2%) | Reference group | |
| Moderately reduced | 42 (14.8%) | 2.44 (0.89 – 6.74) | |
| Severely reduced | 85 (30.0%) | 2.42 (1.02 – 5.77) | |
| Symptoms pre-procedure | |||
| Heart failure | 247 (87.3%) | 0.64 (0.28 – 1.46) | 0.29 |
| Angina | 70 (24.7%) | 0.69 (0.29 – 1.66) | 0.41 |
| Syncope | 17 (6.0%) | 0.56 (0.08 – 4.10) | 0.57 |
| Stability pre-procedure | |||
| Shock | 17 (6.0%) | 2.41 (0.94 – 6.20) | 0.07 |
| Critical status | 39 (13.8%) | 3.69 (1.87 – 7.29) | <0.0005 |
| Unstable angina | 37 (13.1%) | 0.63 (0.19 – 2.05) | 0.44 |
| Recent MI | 35 (12.4%) | 0.63 (0.19 – 2.05) | 0.44 |
| Pulmonary HTN | 153 (54.1%) | 2.45 (1.18 – 5.08) | <0.05 |
| Hemodynamic data | |||
| RA pressure (mmHg) | 8.0 (5.0 – 11.0) | 1.10 (1.05 – 1.15) | <0.0001 |
| PCWP (mmHg) | 18.0 (12.0 – 24.0) | 1.05 (1.01 – 1.08) | <0.05 |
| CO (1/min) | 4.1 (3.4 – 5.0) | 0.82 (0.63 – 1.07) | 0.15 |
| Mean transvalvular gradient (mmHg) | 42.0 (32.0 – 56.0) | 1.00 (0.99 – 1.02) | 0.73 |
| AVA (cm2) | 0.60 (0.50 – 0.80) | 0.21 (0.03 – 1.49) | 0.12 |
Values displayed are mean values ± standard deviation or median values (interquartile range) based of the normalcy of distribution or n (%) for categorical variables.
AVA = aortic valve area; BSA = body surface area; CO = cardiac output; COPD = chronic obstructive pulmonary disease; CV = cardiovascular; HTN = hypertension; LV = left ventricle; MI = myocardial infarction PCWP = pulmonary capillary wedge pressure; RA = right atrial