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. Author manuscript; available in PMC: 2012 Aug 5.
Published in final edited form as: Mol Immunol. 2010 Nov 26;48(4):610–622. doi: 10.1016/j.molimm.2010.10.023

Fig. 7.

Fig. 7

Altered spectrum of somatic point-mutations in the IgH chain intronic JH4-iEμ DNA of Peyer’s patch germinal center (PNAhiB220+) B cells from EndoG−/− mice. (A) Pie charts depict the proportion of sequences carrying various numbers (along margins) of mutations over the 720-bp JH4-iEμ DNA sequences downstream of rearranged VJ558DJH4 DNA in PNAhiB220+ B cells from Peyer’s patches of one pair of 10 week-old and one pair of 28 week-old non-intentionally immunized EndoG−/− and EndoG+/+ littermates. The numbers of the sequences from each mouse analyzed are at the center of the pies. Numbers and nature of independent mutational events scored. Frequencies of point-mutations from each mouse are indicated. (B) Compilations, with the numbers indicating percentages of all mutations scored in the pool of the target sequences. Below the compilations, the ratio of mutations at dG/dC to those at dA/dT is indicated, as is the ratio of transition:transversion substitutions at dG/dC and dA/dT.