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Alternative schematic mechanisms resulting in cytokinergic cross-linking of IgE-FcεRI complexes. Complexes are cross-linked (A) by receptor-bound IgE Fabs contacting regions of neighboring IgE-FcεRI complexes or (B) by bridging with free IgE or (C) bridging by other proteins such as HRF or autoantigens. Free IgE and HRF dimer or multivalent autoantigen are shown in yellow.
