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. Author manuscript; available in PMC: 2012 Aug 6.
Published in final edited form as: J Immunol. 2010 Nov 12;185(12):7262–7273. doi: 10.4049/jimmunol.1000751

Figure 1. Pre-existing immunity to vaccinia limits the MVA insert-specific cellular immunity elicited by a DNA/MVA SIV vaccine.

Figure 1

(A) SIV (Gag, Env and Pol)-specific IFNγ producing CD8 T cell responses. (B) VV-specific IFNγ producing CD8 T cell responses. (C) SIV (Gag, Env and Pol)-specific IFNγ producing CD4 T cell responses. (D) VV-specific IFNγ producing CD4 T cell responses. Closed symbols represent Mamu A*01 positive animals and open symbols represent Mamu A*01 negative animals. Boxes represent medians with 25th and 75th percentiles for the group. Key to animal names is presented in Figure 3B. DN, Dryvax-naïve (n=8); DI, Dryvax-immune (n=8).