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Malignant cells from Lin28b lymph nodes resemble TFH cells. (A) FACS plots describing tumor cell phenotype from mouse 6502. Analyses for CD44/CD62L, CXCR5/PD1, and CD44/CD25 were gated on the CD4+ population. (B) Expression of Bcl6, Cxcl13, Icos, and Il21 in Lin28b tumors. Lanes 1 through 6, WT CD4+ splenocytes, 6502 LN, 6222 LN, 6208 LN, 6297 LN, and w (water).
