Table 5.

Effect of DEC Treatment Prior to High Doses of NDHS (0.2 or 0.4 mmol/kg) Administration on Renal Parameters^a

Renal Parameters	DEC/NDHS 0.2 mmol/kg		DEC/NDHS 0.4 mmol/kg
	− NDHS	+ NDHS	− NDHS	+ NDHS
Urine Volume (ml)
Day 0	9.2 ± 1.7	8.3 ± 0.2	10.9 ± 1.0	11.0 ± 1.8
Day 1	8.8 ± 1.6	27.3 ± 1.7b,c	8.5 ± 0.4	24.0 ± 1.8b,c
Day 2	6.3 ± 0.5	34.4 ± 5.0b,c	6.4 ±0.8b	28.2 ± 5.8b,c
Proteinuria (mg/6 hr)
Day 0	3.4 ± 0.9	2.7 ± 0.2	3.2 ± 0.1	2.9 ± 0.4
Day 1	3.6 ± 0.5	59.5 ± 36.5	3.1 ± 0.2	22.9 ± 6.9b,c
Day 2	1.9 ± 0.1	6.5 ± 2.0	2.4 ± 0.2b	5.2 ± 1.3
Kidney Weight (g/100 g body wt.)	0.38 ± 0.01	0.51 ± 0.01c	0.38 ± 0.01	0.55 ± 0.03c
BUN (mg/dl)
Day 0	20.0 ± 0.4	18.4 ± 1.0	22.1 ± 1.0	20.8 ± 1.4
Day 2	12.1 ± 0.8b	72.2 ± 36.0	11.0 ± 0.1b	125.6 ± 43.6c
S/M Ratio
PAH	3.2 ± 0.2	3.5 ± 0.1	5.5 ± 0.3	2.4 ± 0.4c
PAH + LAC	8.3 ± 0.3	8.5 ± 0.9	14.9 ± 0.4	6.2 ± 0.5c
TEA	16.1 ± 0.9	15.8 ± 0.9	23.3 ± 0.4	14.4 ± 0.6c

^aValues are means ± S.E. for N=4 rats per group. DEC (250 mg/kg, i.p.) was given 1 hr prior to NDHS (0.2, 0.4 mmol/kg) or vehicle administration.

^bSignificantly different from day 0 value within a group, P<0.05.

^cSignificantly different from the appropriate pair-fed control group value for that day’s measurement, P<0.05.