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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Cell Microbiol. 2012 Mar 28;14(6):869–881. doi: 10.1111/j.1462-5822.2012.01762.x

Fig. 7.

Fig. 7

Proposed model of HII-phase membrane disruption. In this model, the acyl group of LtxA initially contacts the cell membrane, and the toxin undergoes a conformational change in which part of the toxin inserts into the membrane. This induces formation of an isotropic phase, resulting in a destabilization of the membrane.