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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: J Immunol. 2012 Apr 2;188(9):4278–4288. doi: 10.4049/jimmunol.1101291

FIGURE 2.

FIGURE 2

Despite Treg expansion, CD4+ T, CD8+ T, and γδ T effectors were still increased in blood and pulmonary compartment after intermittent 5-d IL-2 treatments during M. tuberculosis infection. (A) Representative cytometry histograms of T effector cells measured by ICS with or without Ag stimulation at day 5 after the second IL-2 or saline treatment (day 20 after M. tuberculosis infection). (B) Compares effector cells detected by ICS after in vitro stimulation with pooled Ag85B and ESAT6 peptides, and HMBPP (for Vγ2Vδ2+ T effectors), respectively. n = 6/group. *p < 0.05 and **p < 0.01, respectively, for comparisons between IL-2–treated and control groups. (C) Frequencies of CD8+, CD4+, and Vγ2Vδ2+ T effector cells measured by ICS without Ag stimulation between the control and IL-2–treated groups are compared. n = 6/group. (D) Frequencies of blood T effector cells producing IL-17 after in vitro Ag85B/ESAT6 stimulation between the control and IL-2–treated groups are compared. n = 5.